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M9490697.TXT
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1994-09-24
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Document 0697
DOCN M9490697
TI Cervical intraepithelial neoplasia and human papillomavirus infection
among Senegalese women seropositive for HIV-1 or HIV-2 or seronegative
for HIV.
DT 9411
AU Seck AC; Faye MA; Critchlow CW; Mbaye AD; Kuypers J; Woto-Gaye G;
Langley C; De EB; Holmes KK; Kiviat NB; Department of Infectious
Diseases, University of Dakar, Senegal.
SO Int J STD AIDS. 1994 May-Jun;5(3):189-93. Unique Identifier : AIDSLINE
MED/94339222
AB Studies in various regions of the world have shown that women infected
with HIV-1 are at increased risk for cervical human papillomavirus (HPV)
infection as well as for cervical cancer precursor lesions. HIV
infection and cervical cancer are both widespread in West Africa, but
little is known about the relationship between HPV and HIV-2, which is
the predominant type of HIV in the general population of many West
African countries. To address this issue, we collected cervical samples
for cytology and HPV analysis from 93 women presenting to the University
of Dakar Infectious Disease Service (18 women with HIV-1 infection, 17
with HIV-2 infection, and 58 HIV seronegative controls). Compared to
those without HIV infection, HIV seropositive women were 13.1 (95% CI =
2.4, 128) and 11.0 (95% CI = 3.5, 35.8) times more likely to have HPV
detected using Southern transfer hybridization (STH) and the polymerase
chain reaction (PCR) respectively. Detection of high and intermediate
risk HPV types were significantly associated with HIV-1 and HIV-2
infection. Among HPV positive women, those with, as compared to those
without HIV infection were more likely to harbour high risk HPV types
(OR = 9.2, 95% CI = 0.97, 433). HIV-1 and HIV-2 seropositive women were
23.3 (95% CI = 2.9, 209) and 9.3 (95% CI = 1.1, 79) times more likely to
have cytological diagnosis of dysplasia, respectively, than were HIV
seronegative women. Biopsy-proven CIN 3 was found in one woman with
HIV-1 and invasive cancer was found in one woman with HIV-2.(ABSTRACT
TRUNCATED AT 250 WORDS)
DE Blotting, Southern Cervical Intraepithelial
Neoplasia/COMPLICATIONS/*EPIDEMIOLOGY Cervix
Dysplasia/COMPLICATIONS/EPIDEMIOLOGY Cervix
Neoplasms/COMPLICATIONS/*EPIDEMIOLOGY Female Human *HIV
Seronegativity *HIV Seropositivity HIV-1/*IMMUNOLOGY
HIV-2/*IMMUNOLOGY *Papillomavirus, Human Papovaviridae
Infections/COMPLICATIONS/*EPIDEMIOLOGY Polymerase Chain Reaction
Regression Analysis Senegal/EPIDEMIOLOGY Support, U.S. Gov't, P.H.S.
Tumor Virus Infections/COMPLICATIONS/*EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).